Flexeril Drug Interactions

Flexeril (cyclobenzaprine) is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with Flexeril (cyclobenzaprine).

Major Interactions
Atapryl, Azilect, Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Carbex, Cena K, Chem Mart Tramadol, Darvon, Darvon-N, Dromadol SR, Dromadol XL, Ed K+10, Eldepryl, Emsam, furazolidone, Furoxone, GenRx Tramadol, GHB, Glu-K, iohexol, iopamidol, Iopamidol-370, isocarboxazid, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, Jumex, K + Potassium, K-10, K-8, K-Dur 10, K-Dur 20, K-Lor, K-Norm, K-Sol, K-Tab, K-Vescent (Potassium Chloride), Kaochlor, Kaochlor S-F, Kaon-CI, Kaon-CL 10, Kaon-CL 20%, Kato, Kay Ciel, KCl, KCl-20, Klor-Con, Klor-Con 10, Klor-Con 8, Klor-Con M10, Klor-Con M15, Klor-Con M20, Klor-Con/25, Klotrix, Larapam SR, Marplan, Matulane, metrizamide, Micro-K, Micro-K 10, Myelo-Kit, Nardil, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, Parnate, PC-10, phenelzine, potassium chloride, potassium chloride extended release, potassium citrate, PP-Cap, procarbazine, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, rasagiline, Rum-K, selegiline, Selgene, Slow-K, sodium biphosphate, sodium oxybate, Ten-K, Terry White Chemists Tramadol, Topamax, Topamax Sprinkle, topiramate, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, tranylcypromine, Twin-K, Ultram, Ultram ER, Urocit-K, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Xyrem, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zelapar, Zonegran, zonisamide, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL

Moderate Interactions
40 Winks, A-Spas S/L, Abilify, Abilify Discmelt, acebutolol, acetylcarbromal, acetylcholine ophthalmic, acrivastine, Actiq, Adapin, Adgan, Adsorbocarpine, AHist, Akarpine, Akineton HCl, alcohol, alcohol, ethyl, Aler-Dryl, Aler-Tab, Alfenta, alfentanil, All Day Allergy, Aller-Chlor, Allergia-C, Allerhist-1, Allermax, Alphagan, Alphagan P, alprazolam, alprazolam extended release, Altaryl, amantadine, Ambien, Ambien CR, amitriptyline, amobarbital, amoxapine, Amytal Sodium, Anafranil, Anaspaz, Anergan 50, Antiflex, Antilirium, Antinaus 50, Antivert, APO-Go, APO-Go Pen, Apokyn, apomorphine, apraclonidine ophthalmic, aprepitant, Aquachloral Supprettes, Aquacot, Aquatensen, Aricept, Aricept ODT, aripiprazole, Artane, Asendin, Astelin, Astramorph PF, Atarax, atazanavir, atenolol, Ativan, Atreza, AtroPen, atropine, Aventyl HCl, Avinza, azatadine, azelastine nasal, B-Vex, baclofen, Banaril, Banflex, Banophen, Beldin, Belix, belladonna, Belladonna Tincture, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, benazepril, Benoject-50, Bentyl, Benzacot, benztropine, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, Bidhist, biperiden, bisoprolol, Bonine, bosentan, Brevibloc, brimonidine ophthalmic, Bromaphen, bromocriptine, bromodiphenhydramine, brompheniramine, brompheniramine extended release, BroveX, BroveX CT, Buprenex, buprenorphine, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, butalbital, Butisol Sodium, butorphanol, butorphanol nasal, Bydramine, C.P.M., Calm-Aid, Cantil, carbachol ophthalmic, carbamazepine, carbamazepine extended release, Carbatrol, carbetapentane, carbinoxamine, carbinoxamine extended release, Carbinoxamine PD, Carboptic, Carboxine, Cardioquin, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, carisoprodol, carteolol, Cartia XT, Cartrol, carvedilol, carvedilol extended release, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Celexa, Celontin, Cerebyx, Cesamet, cetirizine, Chlo-Amine, Chlor-Al Rel, Chlor-Mal, Chlor-Phen, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, chloral hydrate, chlordiazepoxide, chlormezanone, Chlorphen, chlorpheniramine, Chlorpheniramine (Allergy), chlorpheniramine 24 hour extended release, chlorpheniramine extended release, chlorproMAZINE, chlorproMAZINE extended release, ChlorTan, citalopram, clemastine, clidinium, clomiPRAMINE, clonazepam, clonidine, clonidine topical, Clopine, clorazepate, clorazepate extended release, clozapine, Clozapine Synthon, Clozaril, codeine, codeine phosphate, codeine sulfate, Codimal A, Cogentin, Cognex, Compazine, Compazine Spansule, Compoz Nighttime Sleep Aid, Compro, Comtan, conivaptan, Contac 12 Hour Allergy, Cophene B, Cordron NR, Coreg, Coreg CR, Corgard, cyclizine, Cymbalta, cyproheptadine, Cystospaz, Cystospaz-M, D-Vert, Dailyhist-1, dalfopristin, Dalgan, Dalmane, darifenacin, dasatinib, Dazidox, Dehydrated Alcohol, demecarium bromide ophthalmic, Demerol HCl, Denzapine, Depacon, Depakene, Depakote, Depakote ER, Depakote Sprinkles, DepoDur, desipramine, desvenlafaxine, Desyrel, Desyrel Dividose, Detrol, Detrol LA, dexbrompheniramine, dexchlorpheniramine, dexchlorpheniramine extended release, dexmedetomidine, dezocine, Di-Phen, Diamode, Diar-Aid, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, Dicyclocot, dicyclomine, dihydrocodeine, Dilacor XR, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dilaudid, Dilaudid-5, Dilaudid-HP, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, dimenhyDRINATE, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diprivan, Diskets, disopyramide, disopyramide extended release, Ditropan, Ditropan XL, Diurese, divalproex sodium, divalproex sodium extended release, Dizac, DMH, Dolophine, Doloral, Doloral Sirop, donepezil, Donnamar, Doral, doxepin, doxepin topical, doxylamine, DPH, Dramamine, Dramamine II, Dramoject, Driminate, Driminate II, dronabinol, droperidol, duloxetine, Duraclon, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duramorph PF, Dymenate, Dytan, Dytuss, echothiophate iodide ophthalmic, Ed Chlor-Tan, Ed ChlorPed, Edecrin, Edecrin Sodium, efavirenz, Effexor, Effexor XR, Efidac-24 Chlorpheniramine, Elavil, Emend, Emend 3-Day, Emend for Injection, ENA 713, Enablex, Endep, Endocodone, Enduron, entacapone, Epitol, eplerenone, Equanil, Equetro, escitalopram, Eserine Sulfate Ophthalmic, Eskalith, Eskalith-CR, esmolol, estazolam, eszopiclone, ETH-Oxydose, ethacrynic acid, ethanol, ethosuximide, ethotoin, Ethyl Alcohol, etravirine, Exelon, FazaClo, felbamate, Felbatol, fentanyl, fentanyl topical, Fentora, FK506, flavoxate, Flexoject, Flexon, fluoxetine, fluoxetine extended release, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurazepam, fluvoxamine, fluvoxamine extended release, Fortovase, fosaprepitant, fosphenytoin, gabapentin, Gabarone, Gabitril, galantamine, galantamine extended release, Genahist, Geodon, Gleevec, glycopyrrolate, grepafloxacin, guanethidine, halazepam, Halcion, Haldol, Haldol Decanoate, haloperidol, haloperidol decanoate, Histaject, Histex CT, Histex I/E, Histex PD, Histex Pd 12, homatropine, Humorsol Ocumeter, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hydrate, hydrocodone, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, HyoMax FT, HyoMax SL, HyoMax SR, hyoscyamine, hyoscyamine extended release, Hyosol, Hyospaz, Hyosyne, Hyrexin, Hyzine, IB-Stat, imatinib, imipramine, imipramine pamoate, Imodium, Imodium A-D, Imodium A-D EZ Chews, Imodium A-D New Formula, Imotil, Inapsine, Inderal, Inderal LA, Infumorph, InnoPran XL, Inspra, Intelence, Invega, Invirase, Ionsys, Iopidine, Ismelin, isoflurophate ophthalmic, Isopto Carbachol, Isopto Carpine, itraconazole, J-Tan, J-Tan PD, Kadian, Kao-Paverin, Kaopectate Caplet, Kemadrin, Keppra, Kerlone, Ketalar, ketamine, Ketek, Ketek Pak, Klonopin, Klonopin Wafer, L-hyoscyamine, labetalol, Lamictal, Lamictal Blue, Lamictal CD, Lamictal Green, Lamictal Orange, lamotrigine, lapatinib, Largon, Levatol, Levbid, levetiracetam, Levo-Dromoran, levocetirizine, levomethadyl acetate, Levoprome, levorphanol, LEVRIX, Levsin, Levsin SL, Levsinex SR, Lexapro, Librium, lindane topical, Lioresal, Lioresal Intrathecal, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lodrane 12 Hour, Lodrane 24, Lodrane XR, loperamide, Lopressor, lorazepam, Lotensin, loxapine, Loxitane, Loxitane C, Loxitane IM, Ludiomil, Luminal, Lunesta, Luvox, Luvox CR, Lyrica, M-Eslon, M-Oxy, M. O. S., Maalox Anti-Diarrheal, Maldemar, maprotiline, Marezine, Marinol, MB-TAB, Mebaral, Meclicot, meclizine, Medivert, Mellaril, Mellaril-S, memantine, Meni-D, mepenzolate, meperidine, mephenytoin, mephobarbital, meprobamate, Meridia, Mesantoin, mesoridazine, Metahydrin, methadone, Methadose, methdilazine, methotrimeprazine, methscopolamine, methsuximide, methyclothiazide, metoclopramide, metoprolol, metoprolol extended release, metoprolol succinate, Metoprolol Succinate ER, metoprolol tartrate, mibefradil, midazolam, Mifeprex, mifepristone, Milontin, Miltown, Mio-Rel, Miochol, Miochol-E, Miochol-E System Pak, Miochol-E/Steri-Tags, Miostat, Mirapex, mirtazapine, Mitran, Moban, molindone, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, morphine liposomal, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, Myolin, Mysoline, nabilone, nadolol, nalbuphine, Namenda, Naqua, Nasahist B, Navane, ND-Stat, nefazodone, Nembutal, Nembutal Sodium, Nervine, Neupro, Neurontin, Nightime Sleepaid, nilotinib, Niravam, Nolahist, Norflex, Norflex Injectable, Normodyne, Norpace, Norpace CR, Norpramin, nortriptyline, Nu-Med, Nubain, Nulev, Numorphan HCl, Nytol Caplet, Nytol Maximum Strength, Ocu-Carpine, Ocusert, olanzapine, olopatadine nasal, OMS, Opana, Opana ER, opium, Opium Deodorized, Optimine, Oramorph SR, Orap, Orfro, Orlaam, Ormazine, orphenadrine, orphenadrine extended release, Orphenate, oxazepam, oxcarbazepine, oxybutynin, oxybutynin extended release, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, oxymorphone, oxymorphone extended release, Oxytrol, P-Tann, P-Tex, Palgic, paliperidone, Palladone, Palladone SR, Pamelor, Pamine, Pamine Forte, Paradione, Paral, paraldehyde, paramethadione, Pardryl, Paregoric, Parlodel, paroxetine, paroxetine extended release, paroxetine mesylate, Patanase, Paxarel, Paxil, Paxil CR, PBZ, PBZ-SR, PediaTan, Pediatex, Pediatex 12, Pediox, Pediox-S, Peganone, penbutolol, Pentazine, pentazocine, pentobarbital, Pentothal, Pepto Diarrhea Control, Percolone, pergolide, Periactin, Permax, Permitil, perphenazine, Pexeva, phenacemide, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, phenindamine, pheniramine, phenobarbital, Phenoject-50, phensuximide, Phenurone, phenyltoloxamine, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, Phospholine Iodide, physostigmine, physostigmine ophthalmic, Pilagan with C Cap, Pilocar, pilocarpine nitrate ophthalmic, pilocarpine ophthalmic, Pilopine-HS, Piloptic-1, Piloptic-1/2, Piloptic-2, Piloptic-3, Piloptic-4, Piloptic-6, Pilostat, pimozide, pindolol, Polaramine, Polaramine Repetabs, Posicor, pramipexole, Precedex, pregabalin, Prialt, Priftin, primidone, Pristiq, Pro-Banthine, Pro-Med, procainamide, procainamide 12 hour extended release, procainamide extended release, Procan SR, Procanbid, prochlorperazine, prochlorperazine extended release, Procot, procyclidine, Prograf, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Pronestyl, Pronestyl-SR, Prop-A-Tane, propantheline, propiomazine, propofol, propranolol, propranolol extended release, Prorex, Prosom, protriptyline, Prozac, Prozac Weekly, Prudoxin, pyrilamine, pyrilamine extended release, Pyrlex, Q-Dryl, Q-Dryl A/F, QDALL AR, Quarzan, quazepam, Quenalin, quetiapine, quetiapine extended release, Quin-G, Quin-Release, Quinaglute Dura-Tabs, Quinidex Extentabs, quinidine, quinidine extended release, Quinora, Rapamune, Rapiflux, Rauwolfemms, Rauwolfia 1X, rauwolfia serpentina, Raxar, Razadyne, Razadyne ER, Reglan, Regurin, Remeron, Remeron SolTab, remifentanil, Reminyl, Repreve, Requip, ReQuip Follow on Pack, Requip Starter Kit, ReQuip Starter Pack, Requip XL, Rescudose, reserpine, Restoril, Reyataz, Rezine, Ridramin, rifapentine, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, rivastigmine, RMS, Robinul, Robinul Forte, Rohist, ropinirole, ropinirole extended release, rotigotine, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, RU-486, Ru-Vert-M, Sal-Tropine, Sanctura, Sanctura XR, saquinavir, saquinavir mesylate, Sarafem, Scopace, scopolamine, scopolamine topical, Scot-Tussin Allergy Relief Formula, secobarbital, Seconal Sodium, Sectral, Selfemra, Serax, Serentil, Seroquel, Seroquel XR, sertraline, Serzone, sibutramine, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Siltane, Simply Sleep, Sinequan, sirolimus, Sleep Tab II, Sleep Tabs, Sleep-ettes, Sleep-Eze-3, Sleepinal, sodium valproate, Solfoton, solifenacin, solotuss, Soma, Sominex, Sominex Maximum Strength Caplet, Somnicaps, Somnote, Sonata, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), Sparine, Spasdel, Sporanox, Sprycel, Stadol, Stadol NS, Statex, Stelazine, Sublimaze, Subutex, Sufenta, sufentanil, Surmontil, Sustiva, Symax Duotab, Symax FasTab, Symax SL, Symax SR, Symmetrel, Tacaryl, tacrine, tacrolimus, Talwin Lactate, Tanacof-XR, TanaHist-PD, Tasigna, Tasmar, Tavist, Tavist Allergy, Tavist-1, Taztia XT, Tegretol, Tegretol XR, telithromycin, Temaril, temazepam, Tenormin, tetrahydroaminocrideine, thalidomide, Thalomid, Theraflu Thin Strips Multi Symptom, thiethylperazine, thiopental, thioridazine, thiothixene, Thorazine, tiagabine, Tiazac, Ticon, Tigan, tizanidine, Tofranil, Tofranil-PM, tolcapone, tolterodine, tolterodine extended release, Toprol-XL, Torecan, Total Allergy, Tracleer, Trancopal, Trandate, Transderm-Scop, Tranxene SD, Tranxene T-Tab, traZODONE, Triaminic Allergy, Triaminic Thin Strips Cough & Runny Nose, triazolam, trichlormethiazide, Tridione, trifluoperazine, triflupromazine, Trihexane, trihexyphenidyl, Trilafon, Trileptal, trimeprazine, trimethadione, trimethobenzamide, trimipramine, tripelennamine, Tripohist, triprolidine, triprolidine extended release, Triptone, trospium, trospium extended release, Trux-adryl, Tusstat, Twilite, Tykerb, Ultiva, Uni-Tann, Unisom, Unisom Sleepgels Maximum Strength, Uprima, Urispas, Urotrol, V-Gan-25, V-Gan-50, Valium, valproic acid, Valrelease, Valu-Dryl, Vanadom, Vanatrip, Vaprisol, VaZol, venlafaxine, venlafaxine extended release, Versed, VESIcare, VFEND, Visken, Vistacon, Vistacot, Vistaject-50, Vistaril, Vistaril IM, Vistazine, Vistazine 50, Vivactil, voriconazole, Wal-finate, Xanax, Xanax XR, Xyzal, XYZALL, zaleplon, Zanaflex, Zaponex, Zarontin, Zebeta, Zetran, ziconotide, ziprasidone, Zoloft, zolpidem, zolpidem extended release, Zonalon, Zymine, Zymine XR, Zyprexa, Zyprexa Zydis, Zyrtec, Zyrtec Hives

Minor Interactions
armodafinil, Atrovent, Atrovent HFA, Atrovent Nasal, bexarotene, ipratropium, ipratropium nasal, modafinil, Nuvigil, Provigil, Spiriva, Targretin, tiotropium

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